Background: Preimplantation genetic testing (PGT) enables genetic assessment of embryos generated through in vitro fertilization before embryo transfer. Its applications include testing for chromosomal aneuploidy and monogenic disorders, with potential utility in reducing transmission of serious inherited conditions. Experience with PGT remains relatively underreported in sub-Saharan Africa.
Objective: To describe three successful applications of PGT for differing reproductive indications at a Nigerian fertility centre.
Methods: This descriptive case series reports three couples who underwent in vitro fertilization with PGT at a Kingswill Specialist Hospital, Lagos. Clinical and reproductive information was obtained from medical records. The indications comprised family balancing, a family history of oculocutaneous albinism, and prevention of sickle cell disease. Relevant PGT approaches were incorporated into assisted conception treatment before embryo transfer. Pregnancy and neonatal outcomes were documented.
Results: The first case involved a 39-year-old para 4 woman with four daughters who sought assisted conception with PGT and subsequently delivered twin boys following embryo transfer. The second couple had significant family histories of oculocutaneous albinism and underwent PGT for a monogenic disorder, resulting in the birth of a phenotypically unaffected female infant. In the third case, both partners had HbAS genotypes and had previously had two children with sickle cell disease (HbSS). Following PGT for a monogenic disorder, an unaffected embryo was transferred, resulting in the birth of a male infant with an HbAA genotype.
Conclusion: These cases illustrate the diverse potential applications of PGT in an African assisted-reproduction setting.
Original Article
Sep 30, 2026
165
55
Diverse Applications of Preimplantation Genetic Testing in Assisted Conception at a Nigerian Fertility Centre: A Case Series
International Journal of Evidence-Based Medicine, 1(3), 2026, jebm014, https://doi.org/10.63946/jebm/19462
Publication date: Sep 30, 2026
ABSTRACT
KEYWORDS
Assisted Reproductive Technology In Vitro Fertilization Preimplantation Genetic Testing PGT-A PGT-M Sickle Cell Disease Oculocutaneous Albinism Nigeria
CITATION (Vancouver)
Nwogu CM, Ugwu AO, Iniso J, Rabiu AF, Omopariola SO, Akpan M. Diverse Applications of Preimplantation Genetic Testing in Assisted Conception at a Nigerian Fertility Centre: A Case Series. International Journal of Evidence-Based Medicine. 2026;1(3):jebm014. https://doi.org/10.63946/jebm/19462
APA
Nwogu, C. M., Ugwu, A. O., Iniso, J., Rabiu, A. F., Omopariola, S. O., & Akpan, M. (2026). Diverse Applications of Preimplantation Genetic Testing in Assisted Conception at a Nigerian Fertility Centre: A Case Series. International Journal of Evidence-Based Medicine, 1(3), jebm014. https://doi.org/10.63946/jebm/19462
Harvard
Nwogu, C. M., Ugwu, A. O., Iniso, J., Rabiu, A. F., Omopariola, S. O., and Akpan, M. (2026). Diverse Applications of Preimplantation Genetic Testing in Assisted Conception at a Nigerian Fertility Centre: A Case Series. International Journal of Evidence-Based Medicine, 1(3), jebm014. https://doi.org/10.63946/jebm/19462
AMA
Nwogu CM, Ugwu AO, Iniso J, Rabiu AF, Omopariola SO, Akpan M. Diverse Applications of Preimplantation Genetic Testing in Assisted Conception at a Nigerian Fertility Centre: A Case Series. International Journal of Evidence-Based Medicine. 2026;1(3), jebm014. https://doi.org/10.63946/jebm/19462
Chicago
Nwogu, Chidinma Magnus, Aloy Okechukwu Ugwu, James Iniso, Anas Funtua Rabiu, Samuel Oluwabunmi Omopariola, and Monday Akpan. "Diverse Applications of Preimplantation Genetic Testing in Assisted Conception at a Nigerian Fertility Centre: A Case Series". International Journal of Evidence-Based Medicine 2026 1 no. 3 (2026): jebm014. https://doi.org/10.63946/jebm/19462
MLA
Nwogu, Chidinma Magnus et al. "Diverse Applications of Preimplantation Genetic Testing in Assisted Conception at a Nigerian Fertility Centre: A Case Series". International Journal of Evidence-Based Medicine, vol. 1, no. 3, 2026, jebm014. https://doi.org/10.63946/jebm/19462
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