Keyword: STING
1 result found.
Original Article
International Journal of Evidence-Based Medicine, 1(2), 2026, jebm009, https://doi.org/10.63946/jebm/18910
ABSTRACT:
Introduction: Vesicoureteral reflux (VUR) is one of the most prevalent conditions in pediatric urology, occurring in approximately 1–2% of children; among those presenting with urinary tract infections, VUR is detected in 25–40% of cases. The incidence shows no declining trend and increases annually in line with global population growth.
Methods: This retrospective-prospective, single-center, comparative cohort study enrolled 110 children aged 8 months to 18 years with VUR grades II–IV treated at the Specialized Pediatric Surgical Clinic of Samarkand State Medical University (1989–2022). Patients were allocated to two non-concurrent treatment groups based on the era of admission: the control group (CG, n=32; 1989–2011) underwent open antireflux surgery, and the study group (SG, n=78; 2012–2022) underwent endoscopic correction of VUR (ECVUR). Patients with grades I and V VUR were excluded.
Results: In the SG, the proportion of good outcomes was 78.2%, exceeding that of the CG (65.6%). Unsatisfactory results were 2.9-fold lower (6.4% vs. 18.8%). Hospitalization was significantly reduced from 16.7±3.3 to 5.2±1.2 bed-days (p<0.001). The economic efficiency coefficient improved 3.2-fold. Overall ECVUR efficacy was 93.6% versus 81.2% for open surgery.
Conclusion: Minimally invasive endourological methods demonstrate superior efficacy and safety compared with open antireflux surgery for the treatment of VUR in children.
Methods: This retrospective-prospective, single-center, comparative cohort study enrolled 110 children aged 8 months to 18 years with VUR grades II–IV treated at the Specialized Pediatric Surgical Clinic of Samarkand State Medical University (1989–2022). Patients were allocated to two non-concurrent treatment groups based on the era of admission: the control group (CG, n=32; 1989–2011) underwent open antireflux surgery, and the study group (SG, n=78; 2012–2022) underwent endoscopic correction of VUR (ECVUR). Patients with grades I and V VUR were excluded.
Results: In the SG, the proportion of good outcomes was 78.2%, exceeding that of the CG (65.6%). Unsatisfactory results were 2.9-fold lower (6.4% vs. 18.8%). Hospitalization was significantly reduced from 16.7±3.3 to 5.2±1.2 bed-days (p<0.001). The economic efficiency coefficient improved 3.2-fold. Overall ECVUR efficacy was 93.6% versus 81.2% for open surgery.
Conclusion: Minimally invasive endourological methods demonstrate superior efficacy and safety compared with open antireflux surgery for the treatment of VUR in children.
